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Name of Medicine: Zhu li Jiao nang


Research Background

The Bamboo Juice, which is also called Fresh Bamboo Juice or Light Bamboo Juice or Bamboo Oil, is the juice of light bamboo or green bamboo that belong to the branch of standing grain root. It is a frequently used trad. Ch. Medicine that has antipyretic function and can reduce phlegm. The flavor is sweet. The character is cold and smooth. It belongs to the channels of heart, lung and stomach. It can facilitate every channel and internal organs, reduce phlegm, nourish body and brighten eyes. It can cure several diseases such as lungs fever, phlegm heat, asthma, phlegm blockage, internal heat, apoplexy, worriment, thirst, anemia and perspiration blockage, and etc. The bamboo juice could cure the consumption, asthma, phlegm, child pneumonia, asthmatic tracheitis and bronchus asthma and so on, which were recorded detailedly in several ancient pharmacopoeias such as the <Herbal Introduction>, the <Herbal Property>, the <Herbal Addition> and the <Herbal Annotations>. It has also entered into the list of the <Trad. Ch. Pharmacology> that is a modern pharmacopoeia, in which it is introduced as a medicine of antipyretic and reducing phlegm. The bamboo juice preparations in the past were all liquid, which is inconvenient and easy to be polluted. Capsule not only can conceal the unwell bitter taste and smell, but also can strengthen the activity and increase the utilization ratio of organism. It conforms to the developmental spirit of medical preparation that are ¡°Three Efficiencies¡±(High Efficiency, Rapid Efficiency, Long Efficiency) and ¡°Three Smalls¡±(Small Dosage, Small Toxicity, Small Side Effect).

Theory of Trad. Ch. Medicine


The trad. Ch. medicine believes that the lung is responsible for breath. If the lung is disordered, the internal heat will emerge. The heat damages the lung, and then forms phlegm that would block the arteries and veins of lung and cause several diseases such as the lungs heat, cough, polyphlegm, asthma and stuff chest. The phlegm is the product of visceral misadjustment and metabolic obstacle. If the phlegm forms, it will remain in the body and cause many kinds of diseases. It is also the cause of apoplexy. Worry, indignation, excess of sexual intercourse and work, etc. will make liver fire be high. Additionally, if the diet isn¡¯t controlled or drinking too much, the phlegm will be formed and produce heat. The internal wind carries phlegm to disturb arteries and veins, which will cause apoplexy that can lead to hemiplegia, paralysis and phlegm blockage. Bamboo juice can reduce phlegm and open up blocked arteries and reins. For example, the phlegm can be brought down if it is in head, can be open if it is in chest, can be scattered if it is in four limbs, can benefit if it is in viscus and can circulate if it is in thin. It also can cure epilepsy, convulsion, stupor and aphonia.

Functional Mechanism

Bamboo juice mainly includes many kinds of amino acid, phenol, organic acid and several ions such as potassium, natrium and calcium, among which the main active compositions are three amino acids that are mendong amino acid, guang amino acid and protein amino acid. The mendong amino acid can promote the lymph cell to develop into the mature lymph cell of T type. In addition, it can strengthen auxiliarily the immunity which is beneficial to lighten the extent of inflammation. The guang amino acid¡¯s chemical structure is similar to the structure of several expectorants. The protein amino acid can turn to be the half-guang amino acid that can have an effect with the guang amino acid. The Yuchuang woodphenol is the main composition in bamboo juice to cure cough.

Technological Research Report

The bamboo juice is a frequently used trad. Ch. medicine having the functions of antipyretic and reducing phlegm. It is also applied extensively in clinical uses.

It can be used alone or with other trad. Ch. medicine. The traditional method of concocting bamboo juice is to collect the liquid flown out from the heated fresh bamboo pole firstly, and then to add the preservative to the boiled liquid. Finally, to install it partly into glass bottles, which are convenient to be taken along or transported. However, if the big package of 100ml can¡¯t be used up, it is easy to be polluted. In order to overcome the above disadvantages and according to the ¡°pill or medicinal extract¡± recorded in the traditional methods of using medicine, we adopt the enriched method of low temperature and pressure to make it be dense and produce it to be capsule for clinical use. Capsule can conceal the unwell bitter taste and smell and make the medicine be neat, pleasing to the eye and easy to be taken. Furthermore, it has high utilization ratio of medical organism, powerful stability and convenient transportation. The weight of each bamboo juice capsule is 0.3g which equivalent to 7.5ml bamboo juice. Take 2 to 4 pellets every time, which is equivalent to take 15 to 30 ml bamboo juice of liquid. It conforms to the developmental spirit of medical preparation that are ¡°Three Efficiencies¡±(High Efficiency, Rapid Efficiency, Long Efficiency) and ¡°Three Smalls¡±(Small Dosage, Small Toxicity, Small Side Effect). The clinical and chemical Experiments have proved that the bamboo juice capsule can guarantee the curative effect of preparation type. Therefore, it gains favorable comment from doctors and sufferers.

All of the Bamboo Juice Capsule, Bamboo Juice and KEKE can resist remarkably small rat¡¯s cough that is caused by ammonia water. They can increase remarkably the amount of phenol secreted from the small rat¡¯s respiratory system and have a certain function of smoothing lung and reducing phlegm. They can resist remarkably the penetrating feature of the small rat¡¯s blood capillary and have a certain function of resisting inflammation. In addition, the Bamboo Juice Capsule can resist the temperature rise of experimental rabbit to a certain extent, which illustrates that it has a certain function of allaying a fever. In a word, the Bamboo Juice Capsule can relieve cough, put down asthma, reduce phlegm and resist inflammation.

With the biggest density (0.5g bamboo juice capsule/ml) and biggest volume (0.8ml/20g) of pouring stomach, and according to 20g per 1kg body weight, the small rat is given the bamboo juice capsule for one time in a day. During 14 days, the 20 small rats are all alive. It indicate that the small rat can endure the bamboo juice capsule of more than 20g per 1kg body weight which is equal to 500 times as much as the one day¡¯s dosage of clinical patient weighting 60kg (2 pellets/time and 3 times/day, which mean 1.8g/60kg/day and 0.04g/kg/day).

The Experimental result indicates that every indexes of hematology, blood biochemistry, weight increase and viscus have no remarkable difference with the comparative group of using physiology brine and the general symptoms have no abnormal phenomenon after the experimental groups have taken the bamboo juice capsule for four weeks successively, which illustrate that every dosage group has no toxicity reaction. After stopping to take medicine for two weeks, every index of the experimental group has no remarkable difference with the comparative group of using physiology brine, which illustrates that every dosage group has no delayed toxicity reaction. In a word, when the patients take the bamboo juice capsule for a long time, it has a better security. The dosage of 120g/kg that is equal to 100 times as much as the clinical dosage can be considered as nonpoisonous dosage.

The Result of Clinical Experiment

The clinical experiment on 370 patients of phlegm fever [cough of phlegm fever (chronic bronchitis)] [apoplexy of phlegm fever (energy channels)] indicates:

The bamboo juice capsule has remarkable effect on phlegm fever. Compare with the comparative group, the statistic P index is more than 0.05, which illustrates that they have no remarkable difference.

The bamboo juice capsule has remarkable effect on the cough, difficult expectoration, asthma and stuffy chest caused by the cough of phlegm fever and the trad. Ch. medical symptom of excessive phlegm caused by the apoplexy of phlegm fever (energy channels). Compare with the comparative group, the statistic P index is more than 0.05, which illustrates that they have no remarkable difference.

The clinical experiment also indicates:

The bamboo juice capsule has remarkable effect on the difficult expectoration and stuffy chest caused by the phlegm fever [cough of phlegm fever (chronic bronchitis)]. Compare with the comparative group, the statistic P index is more than 0.05, which illustrates that they have no remarkable difference. Compare with the blank comparative group, the statistic P index is less than 0.05, which illustrates that they have remarkable difference.

The bamboo juice capsule has remarkable effect on the excessive phlegm caused by the phlegm fever [apoplexy of phlegm fever (energy channels)]. Compare with the No.1 comparative group, the statistic P index is more than 0.05, which illustrates that they have no remarkable difference. Compare with the No.2 comparative group, the statistic P index is less than 0.05, which illustrates that they have remarkable difference.

The phlegm is the product of functional misadjustment of viscus. If it forms, it will remain in body, move up and down with breath and be everywhere in body. It is said that the phlegm is the root of all diseases. When the phlegm stagnates in lung, the lung will lose purity and appear cough, asthma and expectorate. When the phlegm confuses atrium, the words will hem and haw. The heat phlegm will appear when the phlegm combines with heat. When cure it, it is suitable to reduce phlegm mainly. It is recorded in the <Herbal Annotations> that the bamboo juice is sweet, cold and smooth, can be antipyretic, moisten heat and dry, reduce phlegm, maintain blood, bright eyes, cure apoplexy, cure phlegm fever and insanity. Therefore, the bamboo juice has antipyretic function and can reduce phlegm. The bamboo juice capsule has a certain curative effect on chronic bronchitis, cough of phlegm fever in the period of acute brain infarction, difficult antipyretic, asthma, stuffy chest and excessive phlegm.

The bamboo juice capsule can¡¯t cure the symptom of child being afraid of wind. Because there are no cases, the experimental observation can¡¯t be carried on.

The bamboo juice capsule has no harmful reaction in clinical experiment, so it is safe to be taken.

The bamboo juice belongs to the capsule type, so it is convenient to be taken and carried, and easy to be stored.

To sum up, the bamboo juice capsule is the same as the bamboo juice liquid. They all have antipyretic effect and can reduce phlegm. They have auxiliary and curative effects on the phlegm fever [cough of phlegm fever (chronic bronchitis)] [apoplexy of phlegm fever (energy channels)]. The curative effect is accurate and safe. It is convenient to be carried and provides a new choice of trad. Ch. medical preparation for clinical symptoms.

The Report of Surveying New Medicine

There are no similar drugs temporarily in domestic and foreign areas.

The Main Composition

Purify the liquid extraction from the light green bamboo to gain the bamboo juice. It mainly includes many kinds of amino acids, carbohydrates and phenols, among which the main active compositions mendong amino acid, guang amino acid, protein amino acid and yuchuan woodphenol.

Characteristics

Capsule type. The inside is light yellow or light brown things small and roundish. It tastes a little sweet.

Specifications and Package

0.3g per pellet. 24 or 36 or 48 pellets per bottle.

Method and Dosage of Use

Oral medication. 2 or 4 pellets per time, 3 times per day, or obey doctor¡¯s instructions.

Poisonous and Side Effect

Proofed by the experiment of acute and long-term toxicity on small rats, the bamboo juice capsule has no poisonous and side effect.

Applicable Scope

It is used for kinds of symptoms such as cough, excessive phlegm, fever, asthma, stuffy chest, etc. that are caused by the infection of upper part of respiratory system, acute and chronic tracheitis, bronchitis, asthma, pneumonia and so on. It has better curative effect on kinds of symptoms of respiratory system caused by the common cold in summer. It also has auxiliary and curative effects on the brain apoplexy of infarction.

Clinical Data
For a long-term, the bamboo juice is regarded as auxiliary curative medicine of many diseases of phlegm fever type. There are three hospitals such as the affiliated hospital of Chengdu Trad. Ch. Medical University, the first affiliated hospital of Huaxi Medicine University and the affiliated hospital of Sichuan Trad. Ch. Medical Research Institute having carried on clinical experiment in the bamboo juice capsule¡¯s curative effect on the phlegm fever. They observed and evaluated its curative effect and feature of security. According to the principle of stochastic comparison, there were 370 cases being observed, among which there were 220 cases of cough of phlegm fever and 150 cases of disorder of phlegm fever. The result of clinical experiment is that the curative group has display effect ratio of 55% and effective ratio of 31%. The total effective ratio is 86%. It has remarkable effect on the symptoms such as cough, expectorate, stuffy chest caused by the cough of phlegm fever.
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